Tanshinone IIA: A Promising Natural Cardioprotective Agent
نویسندگان
چکیده
منابع مشابه
Tanshinone IIA: A Promising Natural Cardioprotective Agent
Tanshinone IIA (Tan IIA) is a member of the major lipophilic components extracted from the root of Salvia miltiorrhiza Bunge, which is currently used in China and other neighboring countries to treat patients suffering from myocardial infarction (MI), angina pectoris, stroke, diabetes, sepsis, and other conditions. However, Tan IIA is not easy to be absorbed through intestinal pathway. To raise...
متن کاملTanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion.
Tanshinone IIA (Tan IIA), an active component derived from Salvia miltiorrhiza root, has been used to treat various ischemic cardiovascular and cerebrovascular diseases. However, its impact on hepatic ischemia/reperfusion (I/R) injury remains unclear. Here, we addressed this issue by using a 90-minute partial liver ischemia model. Mice were administered Tan IIA intragastrically for 3 days befor...
متن کاملCardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy
AIMS Diabetic cardiomyopathy, characterized by myocardial structural and functional changes, is a specific cardiomyopathy develops in patients with diabetes mellitus. The present study was to investigate the role of kinin B2 receptor-Akt-glycogen synthase kinase (GSK)-3β signalling pathway in mediating the protective effects of tanshinone IIA (TSN) on diabetic cardiomyopathy. METHODS AND RESU...
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Today, science has a better understanding of why fruits and vegetables should be part of a healthy eating plan. Polyphenols are common constituents of the human diet, present in most foods and beverages of plant origin. They are considered to contribute to the prevention of various degenerative diseases, including cardiovascular diseases. Resveratrol is a polyphenol that occurs naturally in gra...
متن کاملTanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma
Objective(s): Tanshinone IIA (T. IIA), one of the most pharmacologically active components extracted from Salviae miltiorrhiza, has anti-inflammatory and antioxidant features. The aim of the present study is to investigate the benefit of T. IIA on asthma using a murine model of asthma induced by ovalbumin (OVA). Materials and Methods: Male BALB/c mice were used in the present study. The mice we...
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ژورنال
عنوان ژورنال: Evidence-Based Complementary and Alternative Medicine
سال: 2012
ISSN: 1741-427X,1741-4288
DOI: 10.1155/2012/716459